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however, the underlying etiology and pathophysiology remains to be fully elucidated Emerging evidence suggests that both an early and aberrant activation of the pain system, as well as an impaired antinociceptive system, contribute to the development of clinical pain Current treatment recommendations include both pharmacological and nonpharmacological therapies Understanding of, treatment options for and social acceptance of fibromyalgia have improved over the past decade, but fibromyalgia remains a scientific and clinical challenge This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF