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Zonulin (Z01/2), Claudin, Occludin and the JAM family proteins regulate how permeable the paracellular space is – i.e., intestinal permeability or “leaky gut.” In this state of increased intestinal permeability or hyperpermeability, organisms, toxins, proteins or pathogens which are normally not absorbed are able to pass through the enterocyte intestinal layer and barrier and enter the body