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Iron overload increases the severity of inflammatory processes, in which there is not only a consistent relationship between seizures and inflammatory cytokines (IL-6, TNF-α, and IFN, etc.) but also the inflammation itself generates increased iron deposits [7]

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doi:10.3389/fphys.2022.848261 William Coetzee, Reiner Khumalo, Brendan Le Roux, Ebrahim Van Wyk