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Although the lack of any toxic effects in this study suggests that the maximum tolerated dose was not achieved, it appears that the high dose in this study was approaching a maximum tolerance dose (MTD), based on the mild body weight effects noted at 140 mg/kg per day in a 12-month study and at 240 mg/kg per day in a two-generation reproductive study

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Flow cytometry demonstrated elevated CTLs in spleens and activated DCs in DLNs (Fig