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A 2025 medicinal-chemistry paper by Fischer Munch and colleagues in the Journal of Medicinal Chemistry described the design and preclinical profile of petrelintide as a selective amylin-receptor agonist, offering a further contrast to cagrilintide's dual AMY/CT pharmacology

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Future studies with other models in which pulmonary vascular remodeling occurs (e.g., Sugen‐hypoxia or monocrotaline) may further clarify the effect of l‐carnitine supplementation on RV dysfunction