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When it comes to 1-MNAM, an often-overlooked product of vitamin B3 elimination, a newly published study found that 1-MNAM secreted by NNMT-expressing tumor cells was elevated in T cells and induced T cells to secrete the tumor-promoting cytokine tumor necrosis factor α (TNFα) in human ovarian cancer [52]

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[DOI] [PMC free article] [PubMed] [Google Scholar] Zeng M, et al