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En el ciclo de Krebs hace que el ácido pirúvico pase por las etapas de piruvato activo y acetaldehído activo y finalmente mediante la intervención del ácido tióctico o ácido lipóico se acetila la coenzima A obteniendo acetil-coenzima A, sustrato primordial del metabolismo oxidativo de los carbohidratos

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Such cases are rare but serious