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The N-terminal fragment of GSDME perforates the cell membrane and causes pyroptosis ( via a mechanism independent of caspase-1/11 ( 3 Potential mechanisms of pyroptosis after ICH 3.1 Pyroptosis caused by the classical pathway NLRP3/caspase-1 after ICH Caspase-1 activation is the key factor in the classical pathway of pyroptosis ( Figure 2 )