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Together, these findings suggest that cellular resistance to cuproptosis also depends on a hierarchically organized copper-buffering system, in which mtGSH provides rapid, dynamic metal buffering, whereas metallothioneins confer sustained high-affinity sequestration to prevent mitochondrial copper overload

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Size:138 ml

[DOI] [PubMed] [Google Scholar] 189.Berridge MJ, Lipp P, Bootman MD