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We also included MS-DRGs 224 and 225 (Cardiac Defibrillator Implant with Cardiac Catheterization without AMI, HF or Shock with and without MCC, respectively) and MS-DRGs 226 and 227 (Cardiac Defibrillator Implant without Cardiac Catheterization with and without MCC, respectively) in our analysis as the logic for these MS-DRGs is similar, differing only in the reporting of a diagnosis that describes acute myocardial infarction, heart failure or shock, or the performance of cardiac catheterization

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Since most of the patients (77.5% in this study) expressed CYP3A4 at normal/high level and approximately one-half of the patients were slow acetylators, high plasma concentrations of 7-amino-clonazepam were anticipated in 35% to 40% of patients (38/98 in this study)