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Senomorphics: Modulating the Senescence-Associated Secretory Phenotype (SASP) Unlike senolytic therapies that aim to directly eliminate senescent cells, senomorphics work by modulating the senescence-associated secretory phenotype (SASP), which consists of pro-inflammatory cytokines, chemokines, growth factors, and extracellular matrix-degrading enzymes secreted by senescent cells

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Clinicians considering this compound for patients should weigh the 2023 FDA guidance on compounded BPC-157 alongside the absence of approved human indications