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Elevation in homocysteine is expected with cobalamin deficiency due to reduced methionine synthase activity even in the face of extreme cobalamin deficiency

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Although research is scarce in this area, several studies have demonstrated that THOT may have potential benefits in the healing of DFUs, ulcers associated with sickle cell disease, as well as in the treatment of stubborn and painful wounds when used as an adjuvant (255, 257)