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Medication risks and side effects in interstitial cystitis management. Jason Gilleran, MD Oakland University William Beaumont School of Medicine joins Alan Wein, MD, PhD(hon), FACS University of Miami, reviewing oral medication risks
Depending on the specific formulations, some prefer using them at different times of the day or alternating their use
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Important unanswered questions include: Long-term exposure Human pharmacokinetics Appropriate exposure levels Drug interactions Effects on methylation pathways Effects on NAD+ metabolism Effects across different tissues Potential off-target effects NNMT participates in normal metabolism, so researchers need to understand not only what happens when the enzyme is inhibited, but also what the consequences of sustained inhibition might be