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Pemetrexed administered intraperitoneally at doses of ≥0.1 mg/kg/day to male mice (approximately 0.006 times the recommended human dose based on BSA) resulted in reduced fertility, hypospermia, and testicular atrophy

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Endogenous antioxidants help maintain oxidative status by delaying, inhibiting, or preventing oxidation by scavenging free radicals [2,3] and include the enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase and the non-enzymatic antioxidants such as glutathione, thioredoxin, and peroxiredoxins (Fig