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miR-21 shows context-dependent effects: by suppressing PTEN it elevates AKT and can acutely enhance NRF2/ARE responses, whereas chronic AKT→mTOR/S6K signaling may impair proximal insulin signaling and favor insulin resistance (40, 89–92)

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Higher dose of CD34/kg infused was associated with faster neutrophil recovery post-HSCT, and to a more limited scale faster platelet recovery