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1 Introduction Parkinson’s disease (PD) is the most common movement disorder and the second most prevalent neurodegenerative disease ( Given the incomplete understanding of PD’s underlying pathological mechanisms, current therapeutic strategies primarily offer symptomatic relief rather than halting disease progression

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Ultimately, strategic combinations of MDSC checkpoint blockades with ICIs, and CAR-based therapies, have the potential to overcome the various immunosuppressive mechanisms present in tumors