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Can Vitamin B12 Cause Acne? | CLEARSTEM

Challenges in scalable, GMP-compliant manufacturing—particularly batch-to-batch variability in encapsulation efficiency (21–94% for PLGA NPs)—and long-term biocompatibility assessments (e.g., hepatosplenic accumulation, PEG immunogenicity) remain unresolved

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Moreover, not all methodologies utilized in these studies are properly validated against the gold standard, i.e., the Ussing chamber, and therefore caution is needed in the interpretation of these permeability data