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Ser is a substrate for mitochondrial one‐carbon metabolism, which generates NADPH while converting Ser + tetrahydrofolate (THF) into glycine (Gly) + THF + formate through the activity of serine hydroxymethyl transferase 2 (SHMT2), methylene‐THF dehydrogenase (MTHFD) 2, and MTHFD1L

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