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There is still a lack of preclinical in vitro blood–brain barrier models that can perfectly mimic the brain microenvironment, leading to limitations in the effectiveness of in vitro screening and practical application of nanomedicine carriers

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Postmenopausal insulin resistance Insulin resistance (IR), a state of impaired ability of peripheral tissues to respond to normal circulating insulin, is the predominant defect in type 2 diabetes (type 2 DM) [32]