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For non-normally distributed data, nonparametric two-tailed Mann–Whitney test or Kruskal–Wallis test with Dunn’s test for multiple comparisons correction was used

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Treatment with the long-acting amylin analogue cagrilintide 2 induces 11.8% weight loss in humans over 68 weeks and co-administering cagrilintide with the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide produces 22.7% weight loss over 68 weeks (versus 16.1% for semaglutide alone) 3,4,5,6