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Balduzzi S., Rücker G., and Schwarzer G., “How to Perform a Meta‐Analysis With R: A Practical Tutorial,” Evidence‐Based Mental Health 22, no

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Side effect comparison NSAIDs (Ibuprofen, Naproxen, etc.): Stomach ulcers and bleeding Kidney damage (long-term) Increased heart attack risk Liver stress Opioids: Addiction and dependence Constipation Sedation and cognitive effects Overdose risk Peptides (BPC-157, TB-500, KPV): Minimal side effects Rare: mild headache, fatigue (temporary) No addiction potential No organ damage Safe long-term use Clear winner: Peptides far safer for chronic pain management