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These organs are particularly susceptible to Ag NP-induced oxidative stress, inflammation, and tissue damage due to their roles in detoxification and filtration [265]

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169 A study that included 356 male patients with coronary artery disease calculated a median (middle) testosterone-to-estradiol ratio of 15.8, and found lower testosterone-to-estradiol ratios were associated with higher levels of thromboxane B2 (a marker of blood clot risk) and lower levels of nitric oxide (a marker of vascular health)