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In addition, future studies must establish whether D-CYSee and betaine can overcome physical dependence to fentanyl, since this synthetic opioid has an ever-increasing role in the current opioid crisis (Hosseini et al., 2011), (b) opioids have often different responses (e.g., ventilation, analgesia) in females compared to males (Sarton et al., 1998

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IF has been shown to enhance the gene expression of certain M2 macrophage markers, partly through increasing adiponectin levels [95, 99]