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Specifically, among individuals under 55 years of age, the share of newly diagnosed cases doubled from 11% in 1995 to 20% in 2019 ( 3 Etiological mechanisms of colorectal cancer Colorectal cancer develops from the intricate interplay of environmental and genetic factors ( Lifestyle factors significantly affect CRC susceptibility: daily alcohol intake exceeding 50 g increases the risk by over more than 41% ( Among metabolic syndrome-related factors, a body mass index (BMI) ≥30 kg/m² increases CRC risk by 93% in young women ( Fusobacterium nucleatum is linked to a 58% increase in mortality ( Escherichia coli (harboring the polyketide synthase genomic island) can promote carcinogenesis by inducing DNA double-strand breaks ( At the genetic level, approximately 5–7% of CRC cases are linked to well-defined hereditary syndromes ( CRC pathogenesis involves two distinct precursor pathways: the adenoma-carcinoma pathway, characterized by chromosomal instability (CIN) and accounting for 60–70% of cases ( Sporadic CRC exhibits marked molecular heterogeneity

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