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Most therapeutic peptides lack safety data for breastfeeding and should be avoided Peptides can transfer to breast milk at concentrations of 15-30% of maternal levels Growth hormone-releasing peptides pose the highest theoretical risk to nursing infants Collagen peptides are considered the safest option but still require medical supervision Wait until after weaning to resume most peptide therapies for optimal safety Peptide Transfer to Breast Milk and Infant Safety Peptides can cross into breast milk through passive diffusion and active transport mechanisms