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These data not only provide new mechanistic insight into the role of EHBP1 in hepatic cholesterol metabolism and NASH fibrosis by uncovering the interaction between EHBP1 and other LDL cholesterol-related loci including SORT1, PCKS9, and LDLR, but also elucidate a novel interplay between inflammation and EHBP1-mediated cholesterol metabolism in the context of NASH

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After completing the original intervention, the progress of a subset of the study participants was followed for up to 3 additional years