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Difficulty breathing or chest tightness Swelling of the face, lips, or throat Widespread hives or a rapid-onset rash High fever with spreading redness at the IV site Sudden confusion, rapid heartbeat, or fainting Severe burning or visible tissue discoloration at the IV site These symptoms can signal anaphylaxis, fluid overload, bloodstream infection, or air embolism, all of which need urgent medical care

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3., Kaeberlein, M., Caldwell, S