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Data availability The ChIP-seq, Hi-C and nascent RNA-seq data reported in this paper have been deposited in NCBI’s Gene Expression Omnibus with the GEO series accession codes GSE270574, GSE270576 and GSE270577

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This is why rosacea-prone skin is generally advised toward gentler formulations: anything that adds further irritant load, whether an active ingredient or a harsh carrier, tends to feed the same inflammatory cycle rather than settle it