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GHR is a 638 amino acid long homodimeric receptor with one cytokine receptor homology domain (CRH), a single-pass transmembrane domain, and cytoplasmic intracellular domain (ICD) (Figure 1)

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BTZ treatment activates astrocytes in the dorsal horn of the spinal cord, leading to a reduction in the expression of crucial glutamate transporter proteins, including glutamate transporter-1 and glutamate/aspartate transporter