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In another embodiment, upon an indication by the subject that it is not a likely responder to a cancer therapy (e.g., at least one modulator of one or more targets listed in table 1 and/or table 2), use of such cancer therapy (e.g., at least one modulator of one or more targets listed in table 1 and/or table 2) may be avoided and an alternative treatment regimen (e.g., targeted and/or non-targeted cancer therapy) may be administered