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In some embodiments, the invention encompasses use of one or more cations of the invention to treat obesity or related chronic metabolic condition, including metabolic syndrome, pre-diabetes, type-2 diabetes, obesity-linked diseases (e.g., non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, CVDs, and the like)

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For maintenance therapy in individuals with dietary deficiency, doses of 50–150 micrograms daily are often sufficient and better tolerated