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NAD+ (Nicotinamide Adenine Dinucleotide) is a coenzyme found in all living cells that serves as a critical electron carrier in the mitochondrial electron transport chain and as a substrate for sirtuins (SIRT1-7), PARPs, and CD38

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The gut-immune interface describes the signalling network that connects the intestinal epithelial cells to the immune cells of the lamina propria, situated directly below the epithelium [201]