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Haematological malignancies: Myeloproliferative disorders (polycythaemia vera, chronic myeloid leukaemia) and some lymphomas increase B12-binding proteins, particularly haptocorrin, raising measured serum levels

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Copper coordination chemistry, briefly What makes GHK-Cu distinctive is how the tripeptide binds copper(II): the imidazole nitrogen of histidine, the N-terminal amine, and backbone nitrogens form a coordination geometry that holds the metal ion with high affinity