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doi: 10.3389/fimmu.2022.581854 Received 13 July 2020 Accepted 22 April 2022 Published 19 May 2022 Volume 13 - 2022 Edited by Pietro Ghezzi, University of Urbino Carlo Bo, Italy Reviewed by Manoussa Ethel Fanny, Boston Children’s Hospital and Harvard Medical School, United States