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Histamine, via its H3 receptors (H3Rs), functions as a presynaptic modulator, regulating the release of multiple neurotransmitters including serotonin (5-HT), dopamine (DA), glutamate (GLU), and melanin-concentrating hormone (MCH)—all of which are implicated in the pathophysiology of major depressive disorder (MDD)

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Crucially, because it avoids insulin signalling pathways, it does not change blood glucose levels