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canned diets: 0.03‐0.59 mg/kg dry matter basis).4 The National Research Council (NRC 2006) recommendation for cobalamin fortification is 35 μg/kg dry matter for canine diets, regardless of the canine life stage.5 The concentration of serum cobalamin and cobalamin‐dependent metabolites is not related to the dogs being fed a biologically appropriate raw food diet or a commercial dog food.6 Bound to dietary protein, cobalamin reaches the stomach where it is released by activated pepsinogen and gastric acid.7 Free cobalamin is then bound to haptocorrin (R protein, transcobalamin I) to protect it from bacterial utilization in the proximal GI tract.7 In the duodenum, pancreatic proteases separate cobalamin from haptocorrin, and free cobalamin is bound to intrinsic factor (IF)
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Activation promotes neuronal survival, axon growth, synaptic plasticity