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TNB-738, a fully human antibody with a silenced IgG4, potently inhibits human CD38 enzymatic activity on human immune cells, resulting in a dose dependent increase of intracellular NAD+ levels as well as a downstream increase of sirtuin 1 expression and activity in vitro and in vivo (5)

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Thus, vitamin C and other similar antioxidants may be efficacious treatment options for disorders with underlying iron overload which leads to ferroptosis [118]