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Novel plant-derived exosome-like nanovesicles from Catharanthus roseus : preparation, characterization, and immunostimulatory effect via TNF-α/NF-κB/PU.1 axis

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The ethyl acetate extract of bark showed the lowest Lethal Concentration (LC₅₀) (4.80%), followed by leaf extracted with ethanol LC 50 (5.94%), while leaf ethyl acetate extract showed the highest LC₅₀ of 6.98% (Table 2 and Supplementary Fig