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Interventional diversity is accelerating riboflavin is now paired experimentally with NAD + precursors, B-vitamin complexes, and magnesium in an attempt to exploit pathway complementarity—riboflavin for FAD-linked enzymes, CoQ10 for electron transfer, L-carnitine for acyl transport, and magnesium for excitotoxic buffering

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Local hypoxia leads to a local increase in perhydroxyl radical (a protonated form of superoxide) and activation of the isoprostane lipid peroxidation, which causes damage to mitochondrial hyperstructures