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found that efficacy was consistent across mRNA, DNA, viral vectors, and inactive viruses and that differences in trial design, population characteristics and other factors were stronger contributors to heterogeneity than vaccine modality

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Therapeutic approaches included pigment fragmentation (PICO, Nd:YAG, IPL, PDL), thermal loosening of the scaffold–tissue complex (radiofrequency, high-intensity focused ultrasound, warm application), mechanical dispersion (microcurrent stimulation, ultrasound, normal saline washout, gentle massage), and enzymatic degradation (hyaluronidase, lipase)