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Regarding its anti-inflammatory and anti-androgenic effects, vitamin D potentially diminishes advanced glycation end products (AGEs)-induced androgen synthesis via downregulating the expression of the receptor for advanced glycation end products (RAGE) and further lowers pro-inflammatory cytokine levels via inhibiting the activity of the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway, consequently improving glucose homeostasis (47)

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This was achieved via proinflammatory cytokines and growth factors like IGF-1 and lead to LUTS (problems with urination)