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1 Introduction Glutathione transferases, also known as glutathione-S-transferases (GSTs, E.C.2.5.1.18), are a family of ubiquitous enzymes present from prokaryotes to uni- or multicellular eukaryotes (including humans) ( In addition to their important role in xenobiotic detoxification and antioxidant defense, GSTs have other cellular vital functions, such as involvement in S-glutathionylation reactions of diverse proteins (or post-translational protein modifications), cell signaling, or resistance to chemotherapy drugs used in the treatment of tumors ( By their origin or cellular location, these enzymes can be divided into four main groups: cytosolic (cGST), mitochondrial (mGST), microsomal or MAPEG (Membrane Associated Proteins involved in Eicosanoid and Glutathione metabolism) and GSTsFosA (bacterial fosfomycin resistance proteins) ( Tetrahymena thermophila is a widely used and well-known model eukaryotic microorganism both in molecular biology studies (organism used by Nobel Prize winning researchers) and in studies on the effect of a wide range of environmental toxicants ( Our current knowledge about the superfamily of GSTs from ciliate protozoa is considerably scarce
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[Abstract] Mater Today Bio