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doi: 10.1371/journal.pone.0212192

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Through its genomic actions, the E2–ER complex binds to estrogen response elements (EREs) located in the promoter regions of target genes, thereby promoting the transcriptional upregulation of key melanogenic enzymes, including TYR, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) [37]