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Methodology A literature-based search, covering research reports that have been published the last five years, was performed to retrieve information on the chemistry, health effects, molecular pharmacology, herb–drug interaction, nanotechnology-based drug delivery, and safety of black cumin and TQ from accessible online databases, such as PubMed, Web of Science, Scopus, and Google Scholar, using the key search terms of ‘black cumin’ and chemical constituents, antioxidant, anti-inflammatory, immunomodulatory, neuroprotective, nephroprotective, anti-obesity, cardioprotective, hepatoprotective, anticancer, nanotechnology or toxicity, etc