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Sermorelin was previously FDA-approved under the brand name Geref, both as a diagnostic agent for GH deficiency (Geref Diagnostic, approved 1997) and as a therapeutic agent for pediatric idiopathic GH deficiency

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To begin with, PD patients are more prone to developing Vit B12 deficiency which may be linked to several factors such as typical low-protein diet in LDopa treated PD, delayed gastric emptying due to autonomic dysfunction, bacterial overgrowth along with helicobacter pylori (HP) infection aggravated by the occurrence of constipation (Fasano et al