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Repressive histones, including H3K9me2 and H3K27me3, are generated by PRC2 in the metanephric mesenchyme which surrounds the ureteric bud (which includes quiescent cells with low levels of the Six2 and Lhx1 transcription factors)

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Normally, between 3 and 6 months of treatment with one of these compounds, some improvement could already be seen in seminal parameters such as concentration, motility, and morphology of the spermatozoa