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Each study told part of the story, but no single trial could answer the big picture question: across all available evidence, does microneedling really work, and how does it compare to established treatments

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This review aims to summarize the role of the oxidative stress in the pathogenesis of AD, focusing in the main oxidative products (DNA, protein, and lipid oxidation products), as well as antioxidant therapeutic approaches involving natural products, nanomaterials, hydrogels, and microneedles