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21 Drugs may advantageously affect the CFFL by avoiding unwanted protein-protein interactions and reinstating desirable interactions for misfolded CFTR variants, thereby improving defective proteostasis

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Similarly, a mitochondria-targeted antioxidant molecule reduced pain and improved locomotor and depressive-like behaviours in animals by enhancing SIRT1-mediated antioxidant enzyme activities (SOD and CAT), suppressing proinflammatory markers (TNF-α and NF-κB) and modulating apoptotic pathways (decreased BAX, increased Bcl-2) [105]