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In fact, during the formation of VM, tumor cells express vascular markers represented by VE-cadherin that plays an important role in VM

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Caveolin 1 expression is decreased in many human fibrosis tissues including SSc skin and lung, IPF lung and keloid-derived fibroblasts, which suggest that the caveolin 1-mediated regulatory pathway may represent a new therapeutic opportunity in fibrotic diseases (Wang et al., 2006