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The mechanism by which CO confers protection against liver I/R injury in an ex vivo liver perfusion model was through the p38 MAPK signalling pathway, independent of cGMP, and interestingly, endogenous CO can be substituted with exogenous CO to mitigate I/R insult [78]

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Comparison between in vitro radiosensitivity and in vivo radioresponse of murine tumor cell lines I: parameters of in vitro radiosensitivity and endogenous cellular glutathione levels